反应详情

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of 68 to 72% nitric acid (0.7 g) at 20 to 25° C. The resulting precipitated solid was stirred for 1 hour. The precipitated product was collected by filtration, washed with acetone (15 ml) and dried to give the title compound as white powder (4.0 g).

1. customThe resulting precipitated solid
2. filtrationThe precipitated product was collected by filtration
3. washwashed with acetone (15 ml)
4. customdried