反应详情

温度

42.5 °C

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of benzene sulfonic acid (2.0 g) at 30 to 35° C. The resulting mass was heated at 40-45° C. and maintained for 30 minutes. The resulting mass was cooled at 25-30° C. This was followed by the addition of diethyl ether (50 ml) and stirred for 3 hours. The precipitated product was collected by filtration under nitrogen and washed with diethyl ether (25 ml) and dried under vacuum to give the title compound as off white powder (5.94 g).

1. temperaturemaintained for 30 minutes
2. temperatureThe resulting mass was cooled at 25-30° C
3. filtrationThe precipitated product was collected by filtration under nitrogen
4. washwashed with diethyl ether (25 ml)
5. customdried under vacuum