Citric Acid → Quetiapine Citrate

Participants

Reaction Steps

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of citric acid (1.1 g) at 30 to 35° C. The resulting mass was heated at reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.95 g).

Provenance & Evidence