反应详情

Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).

1. temperatureThe resulting mass heated
2. temperatureto reflux
3. temperaturemaintained for 30 minutes
4. distillationThis was followed by the distillation of acetone
5. customobtained solid
6. customwas further dried under vacuum