HCID 66672614, compound → HCID 66672439, compound

HRID 421600Notes

Reaction equation

HRID 421600 reaction equation
[NH2:1][C:2]1[C:3]([NH:12][C@@H:13]([CH3:20])[CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:4][C:5]([NH:8][CH:9]([CH3:11])[CH3:10])=[N:6][CH:7]=1.Cl.N[C@H](C)/C=C/C(OC)=O>>[NH2:1][C:2]1[C:3]([NH:12][C@H:13]([CH3:20])[CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[N:4][C:5]([NH:8][CH:9]([CH3:10])[CH3:11])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 66672614HCID 66672614, compoundHCID 86611352HCID 86611352, compound

Product 1

HCID 66672439HCID 66672439, compoundYield 75%

Procedure

The title compound was prepared as methyl (4S)-4-({5-amino-2-[(methylethyl)amino]pyrimidin-4-yl}amino)pentanoate with methyl (2E)(4R)-4-aminopent-2-enoate hydrochloride (1.7 g, 10.31 mmol) to give the title compound (2.17 g, 75%): ES-MS (m/z) 282 [M+1]+.

Sources & evidence

ORD record
ord-1b81bd093e3344368522dc161c7fb960
Source dataset
uspto-grants-2012_01
Patent number
US08101588B2

Reaction notes

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