HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Propyl-2-bromopyrimidine → 5-Propyl-2-[4-[2-[4-(tetrazol-1-yl)phenoxymethyl]pyridin-5-yl]piperidin-1-yl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Propyl-2-bromopyrimidine | HCID 10420346 | — |
| Reactant | HCID 67083200 | HCID 67083200 | — |
| Product | 5-Propyl-2-[4-[2-[4-(tetrazol-1-yl)phenoxymethyl]pyridin-5-yl]piperidin-1-yl]pyrimidine | HCID 67083223 | — |
Reaction Steps
The title compound was prepared from tert-butyl 4-[2-[4-(tetrazol-1-yl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate (Example 17) (56 mg, 0.13 mmol) and 5-propyl-2-bromopyrimidine (36 μL, 0.26 mmol) following a procedure analogous to that in Example 48 as a white crystal (6 mg, yield 10%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536176B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-6f42d4a3e9af4de88446a75b733854f2 |
| Source note | uspto-grants-2013_09 |