Acetyl chloride → HCID 178496609, compound

HRID 421622Notes

Reaction equation

HRID 421622 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)C>[CH3:16][O:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620, compound

Product 1

HCID 178496609HCID 178496609, compoundYield 126.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).

Workup

  1. customto reach room temperature
  2. customSolvent was removed in vacuo

Sources & evidence

ORD record
ord-2784ce9424ef45bfacdb67e0e0e9046d
Source dataset
uspto-grants-2012_01
Patent number
US08101588B2

Reaction notes

Loading…