1-(2-Hydroxyethyl)piperazine → HCID 11591066, compound

HRID 421634Notes

Reaction equation

HRID 421634 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][OH:20])[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.OCCN1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[NH:33]1[C:32]2[C:31](=[C:4]([C:2]3[N:3]=[C:4]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)[C:5]4[S:10][C:9]([CH2:11][N:12]5[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][OH:20])[CH2:14][CH2:13]5)=[CH:8][C:6]=4[N:7]=3)[CH:5]=[CH:6][CH:8]=2)[CH:35]=[CH:34]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 57493965HCID 57493965, compound

Product 1

HCID 11591066HCID 11591066, compound

Procedure

Via 2-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-ethanol, prepared from N-(2-hydroxyethyl)piperazine (commercially available).

Sources & evidence

ORD record
ord-b8742fb4dc6e4da6ad8d6afa3a5156c0
Source dataset
uspto-grants-2012_01
Patent number
US08101607B2

Reaction notes

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