3-Bromo-2-methyl-1-propene → 2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	3-Bromo-2-methyl-1-propene	HCID 357785	—
Reactant	2-amino-9H-pyrido[2,3-b]indole-3-carboxamide	HCID 15270984	—
Reactant	2-amino-9-isopropyl-9H-pyrido[2,3-b]indole-3-carboxamide	HCID 24900676	—
Product	2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide	HCID 59513643	59%

Reaction Steps

2-Amino-9H-pyrido[2,3-b]indole-3-carboxamide (5, 196 mg, 0.866 mmol) was alkylated with methallyl bromide (0.131 mL, 1.30 mmol) according to the procedure detailed in the synthesis of 13 to afford 2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide (xii-a, 143 mg, 59%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08101604B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-87784495542e428790c9bc096c17a66e
Source note	uspto-grants-2012_01