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(R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol → (r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol | HCID 11065873 | — |
| 反応物 | (S)-(2-Iodo-1-methyl-ethyl)-carbamic acid tert-butyl ester | HCID 15529790 | — |
| 反応物 | tert-butyl (1-{[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]methyl}cyclopropyl)carbamate | HCID 24901061 | — |
| 反応物 | (s)-Tert-butyl 1-(benzyloxy)-3-iodopropan-2-ylcarbamate | HCID 66675623 | — |
| 反応物 | N-Boc-1-(iodomethyl)cyclopropanamine | HCID 86648312 | — |
| 生成物 | (r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate | HCID 59613115 | — |
反応手順
(R)-tert-butyl 1-(2-amino-3-carbamoyl-9H-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate (xvi-d) was prepared following the procedure detailed in the preparation of 63, substituting (S)-tert-butyl 1-(benzyloxy)-3-iodopropan-2-ylcarbamate (prepared as detailed in the synthesis of xxvii from commercial N-Boc-L-Ser(Bzl)-ol) for tert-butyl[1-(iodomethyl)cyclopropyl]carbamate. NH4OAc QC conditions. M+H=490.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08101604B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-a575ba8bd3ae445683a3b71fc90484e0 |
| 出典メモ | uspto-grants-2012_01 |