2-Chlorobenzoyl chloride → HCID 16730635, compound

HRID 421670Notes

Reaction equation

HRID 421670 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26](Cl)=[O:27]>>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=2[CH3:21])=[CH:3][C:2]=1[NH:1][C:26](=[O:27])[C:25]1[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=1[Cl:23]

Participants

3

Reactant 2

HCID 691102-Chlorobenzoyl chlorideHCID 16730560N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

Product 1

HCID 16730635HCID 16730635, compound

Procedure

N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.182 mmol) was used in general procedure 1 with 2-chlorobenzoyl chloride (0.228 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(2-chlorobenzamido)phenyl)-2-methyl-6-(trifluoromethyl)-nicotinamide. MS (Q1) 469 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-7b9b017330474c179cf3bdc7a36d431e
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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