2-(Morpholin-4-yl)benzoic acid → HCID 16730713, compound

HRID 421677Notes

Reaction equation

HRID 421677 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[Cl:8].[O:23]1[CH2:28][CH2:27][N:26]([C:29]2[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=2[C:31](O)=[O:32])[CH2:25][CH2:24]1>>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=2[CH3:21])=[CH:3][C:2]=1[NH:1][C:31](=[O:32])[C:30]1[CH:34]=[CH:35][CH:36]=[CH:37][C:29]=1[N:26]1[CH2:27][CH2:28][O:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 27765612-(Morpholin-4-yl)benzoic acidHCID 16730560N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

Product 1

HCID 16730713HCID 16730713, compound

Procedure

N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.15 mmol) was used in general procedure 2 with 2-morpholinobenzoic acid (0.167 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(2-morpholinobenzamido)phenyl)-2-methyl-6-(trifluoromethyl)-nicotinamide. MS (Q1) 519.3 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-7f845a9d2ec345b189803fe2ed570187
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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