4-(1,2,3-Thiadiazol-4-yl)benzoic acid → HCID 16730716, compound

HRID 421679Notes

Reaction equation

HRID 421679 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[Cl:8].[S:23]1[CH:27]=[C:26]([C:28]2[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=2)[N:25]=[N:24]1>>[S:23]1[CH:27]=[C:26]([C:28]2[CH:29]=[CH:30][C:31]([C:32]([NH:1][C:2]3[CH:3]=[C:4]([NH:9][C:10](=[O:22])[C:11]4[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[N:13][C:12]=4[CH3:21])[CH:5]=[CH:6][C:7]=3[Cl:8])=[O:33])=[CH:35][CH:36]=2)[N:25]=[N:24]1

Participants

3

Reactant 2

HCID 27764514-(1,2,3-Thiadiazol-4-yl)benzoic acidHCID 16730560N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

Product 1

HCID 16730716HCID 16730716, compound

Procedure

N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.15 mmol) was used in general procedure 2 with 4-(1,2,3-thiadiazol-4-yl)benzoic acid (0.167 mmol). The product was purified by RP-HPLC to give N-(3-(4-(1,2,3-thiadiazol-4-yl)benzamido)-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 518.1 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-3dabfeedd5e7435b8560574b0cceef23
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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