N-(5-amino-2-chlorophenyl)benzamide → N-(3-benzamido-4-chlorophenyl)-6-morpholinonicotinamide

HRID 421682Notes

Reaction equation

HRID 421682 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:17])=[C:6]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1.[O:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][N:25]=2)[CH2:20][CH2:19]1>>[C:9]([NH:8][C:6]1[CH:7]=[C:2]([NH:1][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([N:21]3[CH2:20][CH2:19][O:18][CH2:23][CH2:22]3)=[N:25][CH:26]=2)[CH:3]=[CH:4][C:5]=1[Cl:17])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 721122N-(5-amino-2-chlorophenyl)benzamideHCID 27764606-Morpholinonicotinic Acid

Product 1

HCID 16730791N-(3-benzamido-4-chlorophenyl)-6-morpholinonicotinamide

Procedure

N-(5-amino-2-chlorophenyl)benzamide (0.24 mmol) was used in general procedure 2 with 6-morpholinonicotinic acid (0.30 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-morpholinonicotinamide. MS (Q1) 437.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-bf1f7403bd354735ae3fc8dab0f770ff
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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