2,6-Dimethylpiperazine → Nicotinamide

HRID 421685Notes

Reaction equation

HRID 421685 reaction equation
C(NC1C=C([NH:17][C:18](=[O:26])[C:19]2[CH:24]=[CH:23][C:22](Cl)=[N:21][CH:20]=2)C=CC=1Cl)(=O)C1C=CC=CC=1.CC1CNCC(C)N1>>[C:18]([NH2:17])(=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1

Participants

3

Reactant 2

HCID 660562,6-DimethylpiperazineHCID 16730795HCID 16730795, compound

Product 1

HCID 936Nicotinamide

Procedure

N-(3-benzamido-4-chlorophenyl)-6-chloronicotinamide (0.15 mmol) was used in general procedure 3 with 2,6-dimethylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(3S-,5R)-3-5-dimethylpiperazine-1-yl)nicotinamide. MS (Q1) 464.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-3c9af6fd3a9347daac82f3d5d047de6c
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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