1-Acetylpiperazine → HCID 16730874, compound

HRID 421688Notes

Reaction equation

[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:26])[C:19]2[CH:24]=[CH:23][C:22](Cl)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)(=[O:29])[CH3:28]>>[C:27]([N:30]1[CH2:35][CH2:34][N:33]([C:22]2[CH:23]=[CH:24][C:19]([C:18]([NH:17][C:12]3[CH:13]=[CH:14][C:15]([Cl:16])=[C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:11]=3)=[O:26])=[CH:20][N:21]=2)[CH2:32][CH2:31]1)(=[O:29])[CH3:28]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 16730795HCID 16730795, compound

Product 1

HCID 16730874HCID 16730874, compound

Procedure

N-(3-benzamido-4-chlorophenyl)-6-chloronicotinamide (0.15 mmol) was used in general procedure 3 with 1-acetylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give 6-(4-acetylpiperazin-1-yl)-N-(3-benzamido-4-chlorophenyl)nicotinamide. MS (Q1) 478.0 (M)+

Workup

customThe product was purified by RP-HPLC

Sources & evidence

ORD record: ord-c3f6d06e69564914bb19ac4d24be8c13
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

Loading…