rel-(2R,6S)-2,6-dimethylpiperazine → 2-Methylnicotinamide

HRID 421692Notes

Reaction equation

HRID 421692 reaction equation
C(NC1C=C([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22](Cl)=[N:21][C:20]=2[CH3:26])C=CC=1Cl)(=O)C1C=CC=CC=1.C[C@H]1CNC[C@@H](C)N1>>[CH3:26][C:20]1[N:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:18]([NH2:17])=[O:27]

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 16730950HCID 16730950, compound

Product 1

HCID 122437052-Methylnicotinamide

Procedure

N-(3-benzamido-4-chlorophenyl)-6-chloro-2-methylnicotinamide (0.15 mmol) was used in general procedure 3 with cis-2,6-dimethylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(3S-,5R)-3-5-dimethylpiperazine-1-yl)-2-methyl-nicotinamide. MS (Q1) 464.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-d3918da9c0e34755b6c8087d0fb71996
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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