2-Phenyl-4-carboxythiazole → N-(3-benzamido-4-chlorophenyl)-2-phenylthiazole-4-carboxamide

HRID 421697Notes

Reaction equation

HRID 421697 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:17])=[C:6]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1.[C:18]1([C:24]2[S:25][CH:26]=[C:27]([C:29](O)=[O:30])[N:28]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:9]([NH:8][C:6]1[CH:7]=[C:2]([NH:1][C:29]([C:27]2[N:28]=[C:24]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[S:25][CH:26]=2)=[O:30])[CH:3]=[CH:4][C:5]=1[Cl:17])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 1389282-Phenyl-4-carboxythiazoleHCID 721122N-(5-amino-2-chlorophenyl)benzamide

Product 1

HCID 16731031N-(3-benzamido-4-chlorophenyl)-2-phenylthiazole-4-carboxamide

Procedure

N-(5-amino-2-chlorophenyl)benzamide (0.20 mmol) was used in general procedure 2 with 2-phenylthiazole-4-carboxylic acid (0.25 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-2-phenylthiazole-4-carboxamide. MS (Q1) 434.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-7ee2e7eebe0f40c8ac02935df2ac2b7d
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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