rel-(2R,6S)-2,6-dimethylpiperazine → Nicotinamide

HRID 421699Notes

Reaction equation

HRID 421699 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC(F)=CC=3)C=2)=[O:7])=[CH:4][N:3]=1.C[C@H]1CNC[C@@H](C)N1>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:26]=[CH:27][CH:2]=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 16731033HCID 16731033, compound

Product 1

HCID 936Nicotinamide

Procedure

6-chloro-N-(4-chloro-3-(4-fluorobenzamido)phenyl)nicotinamide (0.15 mmol) was used in general procedure 3 with cis-2,6-dimethylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give N-(4-fluorobenzamido)phenyl)-6-(3S-,5R)-3-5-dimethylpiperazine-1-yl)nicotinamide. MS (Q1) 482.3 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-1b9206f91f5240c1a50283688af9fec7
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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