Propionyl chloride → HCID 16731115, compound

HRID 421700Notes

Reaction equation

HRID 421700 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[N:12][CH:11]=2)=[CH:4][C:3]=1[NH:23][C:24](=[O:32])[C:25]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=1.[C:33](Cl)(=[O:36])[CH2:34][CH3:35]>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([C:24]([NH:23][C:3]2[CH:4]=[C:5]([NH:8][C:9]([C:10]3[CH:11]=[N:12][C:13]([N:16]4[CH2:17][CH2:18][N:19]([C:33](=[O:36])[CH2:34][CH3:35])[CH2:20][CH2:21]4)=[CH:14][CH:15]=3)=[O:22])[CH:6]=[CH:7][C:2]=2[Cl:1])=[O:32])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 16731193HCID 16731193, compound

Product 1

HCID 16731115HCID 16731115, compound

Procedure

N-(4-chloro-3-(4-fluorobenzamido)phenyl)-6-(piperazin-1-yl)nicotinamide (0.182 mmol) was used in general procedure 1 with propionyl chloride (0.20 mmol). The product was purified by RP-HPLC to give N-(3-(4-fluorobenzamido)-4-chlorophenyl)-6-(4-propionylpiperazin-1-yl)pyridine-3-carboxamide. MS (Q1) 510.3 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-feaab2faecee49febd57db3267a057c0
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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