1-Acetylpiperazine → HCID 16731267, compound

HRID 421708Notes

Reaction equation

Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH:10]=2)=[O:7])=[C:4]([CH3:28])[N:3]=1.[C:29]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)(=[O:31])[CH3:30]>>[C:29]([N:32]1[CH2:37][CH2:36][N:35]([C:2]2[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([NH:16][C:17](=[O:25])[C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=4)[CH:10]=3)=[O:7])=[C:4]([CH3:28])[N:3]=2)[CH2:34][CH2:33]1)(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 16731197HCID 16731197, compound

Product 1

HCID 16731267HCID 16731267, compound

Procedure

6-chloro-N-(4-chloro-3-(4-fluorobenzamido)phenyl)-2-methylnicotinamide (0.17 mmol) was used in general procedure 3 with 1-acetylpiperazine (0.868 mmol). The product was purified by RP-HPLC to give 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(4-fluorobenzamido)phenyl)-2-methyl-nicotinamide. MS (Q1) 510.1 (M)+

Workup

customThe product was purified by RP-HPLC

Sources & evidence

ORD record: ord-62834b496cfb4f679a434baaf961579a
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

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