HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-(Piperazin-1-yl)pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide | HCID 16731270 | — |
| Product | 6-(Piperazin-1-yl)pyridine-3-carboxamide | HCID 22028988 | — |
Reaction Steps
6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.16 mmol) was used in general procedure 3 with Boc-piperazine (0.868 mmol). The product was deprotected by treatment with TFA and purified by RP-HPLC to give N-(4-chloro-3-(3-chlorobenzamido)phenyl))-6-(piperazin-1-yl)nicotinamide. MS (Q1) 470.1 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101610B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-51e990a788344679856f79ed6856ade6 |
| Source note | uspto-grants-2012_01 |