4-Amino-1-methylpiperidine → HCID 86624155, compound

HRID 421716Notes

Reaction equation

HRID 421716 reaction equation
Br[CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:8])=[CH:5][N:4]=1.[CH3:29][N:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1>>[CH3:29][N:30]1[CH2:35][CH2:34][CH:33]([NH:36][CH2:2][C:3]2[CH:28]=[CH:27][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][N:4]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 16731357HCID 16731357, compound

Product 1

HCID 86624155HCID 86624155, compound

Procedure

6-(bromomethyl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.2 mmol) was used in general procedure 5 with 1-methylpiperidin-4-amine (0.4 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(3-chlorobenzamido)phenyl))-6-((1-methylpiperidin-4-ylamino)-methyl)nicotinamide. MS (Q1) 512.3 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-17dc7aa4da7d4cddade8f679c8ca9c5e
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

Loading…