1-Acetylpiperazine → HCID 16730158, compound

HRID 421717Notes

Reaction equation

Br[CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([NH:17][C:18](=[O:26])[C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH:11]=2)=[O:8])=[CH:5][N:4]=1.[C:29]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)(=[O:31])[CH3:30]>>[C:29]([N:32]1[CH2:37][CH2:36][N:35]([CH2:2][C:3]2[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([NH:17][C:18](=[O:26])[C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=4)[CH:11]=3)=[O:8])=[CH:5][N:4]=2)[CH2:34][CH2:33]1)(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 16731357HCID 16731357, compound

Product 1

HCID 16730158HCID 16730158, compound

Procedure

6-(bromomethyl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.2 mmol) was used in general procedure 5 with 1-acetylpiperazine (0.4 mmol). The product was purified by RP-HPLC to give 6-((4-acetylpiperazin-1-yl)methyl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide. MS (Q1) 526.0 (M)+

Workup

customThe product was purified by RP-HPLC

Sources & evidence

ORD record: ord-955263f6272c44c99c08cd704cc4ed15
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

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