Nicotinamide → HCID 66677355, compound

HRID 421720Notes

Reaction equation

Cl[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=2)=[O:7])=[CH:4][N:3]=1.[C:21]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)(=[O:23])[CH3:22].C(N)(=O)C1C=CC=NC=1>>[C:21]([N:24]1[CH2:29][CH2:28][N:27]([C:2]2[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=3)=[O:7])=[CH:4][N:3]=2)[CH2:26][CH2:25]1)(=[O:23])[CH3:22]

Participants

Reactant 3

HCID 936Nicotinamide

HCID 837951-Acetylpiperazine

HCID 51180230HCID 51180230, compound

Product 1

HCID 66677355HCID 66677355, compound

Procedure

6-chloro-N-(4-chloro-3-nitrophenyl)nicotinamide (1.6 mmol) was used in general procedure 3 with 1-acetylpiperazine (4.8 mmol to give 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-nitrophenyl))-nicotinamide. MS (Q1) 404.4 (M)+

Sources & evidence

ORD record: ord-7e1ea0ac76334b8b8ed84df760ef1dde
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

Loading…