1-Acetylpiperazine → Nicotinamide

HRID 421723Notes

Reaction equation

HRID 421723 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(F)C=3)C=2)=[O:7])=[CH:4][N:3]=1.C(N1CCNCC1)(=O)C>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:26]=[CH:27][CH:2]=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 16730232HCID 16730232, compound

Product 1

HCID 936Nicotinamide

Procedure

6-chloro-N-(4-chloro-3-(3-fluorobenzamido)phenyl)nicotinamide (0.117 mmol) was used in general procedure 3 with 1-acetylpiperazine (0.35 mmol). The product was purified by RP-HPLC to give 6-(4-acetylpiperazin-1-yl)-N-(3-fluoro-3-(3-chlorobenzamido)phenyl))phenyl)nicotinamide. MS (Q1) 496.1 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-3fa0c72e93ca47209e3654914a428dac
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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