2,6-Dimethylpiperazine → Nicotinamide

HRID 421725Notes

Reaction equation

HRID 421725 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=CC=3F)C=2)=[O:7])=[CH:4][N:3]=1.CC1CNCC(C)N1>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:26]=[CH:27][CH:2]=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 660562,6-DimethylpiperazineHCID 16730302HCID 16730302, compound

Product 1

HCID 936Nicotinamide

Procedure

6-chloro-N-(4-chloro-3-(2-fluorobenzamido)phenyl)nicotinamide (0.177 mmol) was used in general procedure 3 with 2,6-dimethylpiperazine (0.70 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(2-fluorobenzamido)phenyl))-6-(3S,5R)-3-5-dimethylpiperazine-1-yl)nicotinamide. MS (Q1) 482.1 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-e50a1b3f52a944678a1bf38aeed0db5c
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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