rel-(2R,6S)-2,6-dimethylpiperazine → Nicotinamide

HRID 421730Notes

Reaction equation

HRID 421730 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=CC=3Cl)C=2)=[O:7])=[CH:4][N:3]=1.C[C@H]1CNC[C@@H](C)N1>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:26]=[CH:27][CH:2]=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 16730381HCID 16730381, compound

Product 1

HCID 936Nicotinamide

Procedure

6-chloro-N-(4-chloro-3-(2-chlorobenzamido)phenyl)nicotinamide (0.2 mmol) was used in general procedure 3 with cis-2,6-dimethylpiperazine (0.8 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(2-chlorobenzamido)phenyl))-6-(3S,5R)-3-5-dimethylpiperazine-1-yl)-nicotin-amide. MS (Q1) 498.1 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-7e2341aa7ce046268bfe69e9cdad27df
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

Loading…