反应详情

Solid Na2CO3 (200 mg, 1.9 mmol, 1.9 eq) is added to a solution of 1-benzyl-4-chlorophthalazine (250 mg, 0.98 mmol, 1 eq) and (R)-2-methyl-piperazine (400 mg, 4.0 mmol, 4.0 eq) in dioxane (5 mL) in a microwave vial. The vial is sealed and irradiated in the microwave at 150° C. (high absorption setting) for 30 minutes. The reaction mixture is filtered and concentrated, then diluted with EtOAc (50 mL) and water (15 mL). The organic fraction washed with water and then brine, then is dried over sodium sulfate. The solvent is evaporated under reduced pressure to afford the title compound as a white solid (180 mg, 58% yield).

1. customThe vial is sealed
2. customirradiated in the microwave at 150° C. (high absorption setting) for 30 minutes
3. filtrationThe reaction mixture is filtered
4. concentrationconcentrated
5. additiondiluted with EtOAc (50 mL) and water (15 mL)
6. washThe organic fraction washed with water
7. dry with materialbrine, then is dried over sodium sulfate
8. customThe solvent is evaporated under reduced pressure