(3-Trifluoromethylphenyl)urea → HCID 59684815, compound

Participants

Reaction Steps

To a stirred solution of 5-(benzyloxy)hexane-2,4-dione (250 mg, 1.13 mmol; Example 8A), 4-cyanobenzaldehyde (149 mg, 1.13 mmol) and N-[3-(trifluoromethyl)phenyl]urea (232 mg, 1.13 mmol) in tetrahydrofuran (5 ml) is added polyphosphoric acid ethyl ester (700 mg). After 16 hours, the reaction solution is purified directly by preparative HPLC (RP18 column; eluent: acetonitrile/0.1% aq. formic acid 10:90→90:10). The fractions containing product are concentrated and again purified by preparative HPLC (RP18 column; eluent: acetonitrile/0.1% aq. formic acid 10:90→90:10).

Provenance & Evidence