1-(2-Hydroxyethyl)-2-pyrrolidinone → 2-(2-Oxopyrrolidin-1-yl)ethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Hydroxyethyl)-2-pyrrolidinone	HCID 76980	—
Reactant	tert.-Butyl [6-(4-cyanophenyl)-5-(1H-imidazol-1-ylcarbonyl)-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidin-1(2H)-yl]acetate	HCID 59684795	—
Product	2-(2-Oxopyrrolidin-1-yl)ethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate	HCID 59684855	74%

Reaction Steps

The title compound is synthesized in analogy to Example 64 from Example 15A using N-(2-hydroxyethyl)-2-pyrrolidone instead of tert.-butyl-N-hydroxyethyl carbamate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08101615B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-748d4741d2614876b8f34a65a995111a
Source note	uspto-grants-2012_01