Benzyl 2-hydroxyacetate → 2-(Benzyloxy)-2-oxoethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Benzyl 2-hydroxyacetate	HCID 561337	—
Reactant	tert.-Butyl [6-(4-cyanophenyl)-5-(1H-imidazol-1-ylcarbonyl)-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidin-1(2H)-yl]acetate	HCID 59684795	—
Product	2-(Benzyloxy)-2-oxoethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate	HCID 59684853	32%

Reaction Steps

The title compound is synthesized in analogy to Example 64 from Example 15A using benzyl hydroxyacetate instead of tert.-butyl-N-hydroxyethyl carbamate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08101615B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-f30cf32509394f2799f9f20a89f9159d
Source note	uspto-grants-2012_01