(3-Trifluoromethylphenyl)urea → HCID 59684870, compound

Participants

Reaction Steps

9.85 g (48.27 mmol) N-[3-(trifluoromethyl)phenyl]urea, 6.33 g (48.27 mmol) 4-cyanobenzaldehyde, 10.00 g (48.27 mmol) 1-(4-nitrophenyl)butane-1,3-dione and 15 g polyphosphoric acid ethyl ester are suspended in 100 ml of tetrahydrofuran. The mixture is stirred at reflux for 20 hours. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by column chromatography on silica with cyclohexane/ethyl acetate mixtures as eluent.

Provenance & Evidence