HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(methylsulfanyl)aniline → Ethyl 4-(2-fluoro-4-(methylthio)phenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridazine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(methylsulfanyl)aniline | HCID 22025617 | — |
| Reactant | Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridazine-3-carboxylate | HCID 66674070 | — |
| Product | Ethyl 4-(2-fluoro-4-(methylthio)phenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridazine-3-carboxylate | HCID 66674013 | 81% |
Reaction Steps
The title compound was prepared in 81% yield by the procedure described in Example 166 (step H) using ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridazine-3-carboxylat (500 mg, 2.17 mmol) and 2-fluoro-4-methylthioaniline (375 mg, 2.38 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101611B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6eccb4bb41e842ceb60430fd1ac164e4 |
| Source note | uspto-grants-2012_01 |