HCID 66674018, compound → HCID 66675025, compound

Participants

Reaction Steps

Platinum(IV) oxide (0.5 eq.) was added to a solution of methyl 7(R,S)-(cyanomethyl)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.20 M) in MeOH. The atmosphere in the reaction vessel was exchanged for H2, and the reaction stirred vigorously at RT for 4 h. The reaction vessel was flushed with N2, and the reaction mixture filtered through a plug of CELITE (washing well with MeOH and EtOAc). Volatiles were removed in vacuo to afford the crude product which was purified by FC (EtOAc/MeOH/Et3N 93:5:2) affording the product as a yellow oil (12%). (ES+) m/z 433 (M+H)+.

Provenance & Evidence