Hydrochloric Acid → HCID 66674192, compound

Participants

Reaction Conditions

Reaction Steps

KOH (5.0 eq.) was added to a solution of methyl 13-cyclohexyl-6-(2,5-dimethyl-8,8-dioxido-10-phenyl-8-thia-2,5,9-triazadec-1-yl)-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylate (0.02 M) in dioxane/H2O (1/1). The reaction was heated at 60° C. for 4.5 h. The reaction was allowed to cool to RT and acidified with 1N HCl (aq), the mixture was extracted two times with DCM. The combined organics were washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the product (quant.). (ES+) m/z 659 (M+H)+.

Provenance & Evidence