HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 421949Generated: October 30, 2026
Thionyl Chloride → Benzylamine, N-(2-chloroethyl)-N-methyl-, hydrochloride
https://huagongshe.com/reaction/421949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | N-Benzyl-N-methylethanolamine | HCID 66876 | — |
| Product | Benzylamine, N-(2-chloroethyl)-N-methyl-, hydrochloride | HCID 31967 | — |
Reaction Steps
2-[benzyl(methyl)amino]ethanol was added dropwise to an excess of SOCl2 (50 eq.) and the mixture heated at 35° C. for 16 h. Volatiles were removed in vacuo and the residual oil triturated with Et2O to give the title compound as a white solid in quantitative yield. MS (ES+) m/z 184 (M+H)+; 186 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08101595B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-c592461128af44e9a4a34fefaadd00b0 |
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| Source note | uspto-grants-2012_01 |
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