HCID 66676749, compound → HCID 178428259, compound

Participants

Reaction Conditions

Reaction Steps

101 mg of N-(1-tert-butyl-1H-pyrazol-5-yl)-2-(((1S,4S)-5-(3-chloro-2-fluorobenzoyl) -2,5-diazabicyclo[2.2.1]hept-2-yl)methyl)-6-methylpyrimidine-4-amine was dissolved in 1 ml of formic acid followed by stirring at 100° C. for 3 hours. The reaction solution was concentrated in vacuo, diluted with ethyl acetate, and then washed with saturated sodium bicarbonate, water and saturated brine. The resulting organic layer was dried over magnesium sulfate and filtered, and the filtrate was concentrated. The resulting residue was purified by a reversed phase preparative liquid chromatography to give the title compound.

Provenance & Evidence