Water → HCID 178525674, compound

Participants

Reaction Steps

19 mg of 6-(((1S,4S)-5-(2,3-dichlorobenzoyl)-2,5-diazabicyclo[2.2.1]hept-2-yl)methyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyrazine-2-amine was dissolved in 1 ml of trifluoroacetic acid and 0.1 ml of water followed by stirring at room temperature for 15 hours. The reaction solution was concentrated in vacuo, diluted with ethyl acetate, and then washed with saturated sodium bicarbonate, water and brine. The resulting organic layer was dried over magnesium sulfate and filtered, and the filtrate was concentrated. The resulting residue was purified by a silica gel column chromatography (eluent: chloroform to chloroform/methanol=5/1) to give the title compound.

Provenance & Evidence