1-(3-nitro-phenyl)-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-urea → 1-(3-amino-phenyl)-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-urea

Participants

Reaction Steps

1-(3-nitro-phenyl)-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-urea (0.23 g, 0.74 mmol) is dissolved in a mixture of DMF-MeOH. To this solution is added Pd/C (10%, wet, 0.10 g). The reaction is placed under a hydrogen balloon and stirred for 20 hours at room temperature. The catalyst is removed and the solvent is evaporated to give 1-(3-amino-phenyl)-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-urea. LC-MS: 283.1 (MH+).

Provenance & Evidence