Hydrochloric Acid → HCID 16661285, compound

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Reaction Steps

To a solution of 1-acetyl-4-(1-acetyl-1H-indazol-5-yl)-6-[2-(propyloxy)phenyl]pyrimidin-2(1H)-one (1.06 g, 2.46 mmol) in methanol (100 mL) was added hydrogen chloride in dioxane 4.0 N (1.0 mL) and then refluxed for 30 min. The solution was evaporated in vacuo to afford the title compound (0.83 g, 98%) as the di-hydrochloride salt. 1H NMR (400 MHz, d6-DMSO): 8.74 (s, 1H), 8.37 (s, 1H), 8.05 (d, 1H), 7.78 (t, 2H), 7.64 (t, 1H), 7.58 (s, 1H), 7.28 (d, 1H), 7.19 (t, 1H), 4.08 (t, 2H), 1.78 (m, 2H), 0.98 (t, 3H); MS (EI) for C20H18N4O2: 347 (MH+).

Provenance & Evidence