Hydrazine hydrate (1:1) → 6-Chloro-1,2,3,4-tetrahydrophthalazine-1,4-dione

Participants

Reaction Steps

A mixture of 4-chlorophthalic anhydride (1.81 g, 10 mmol) and acetic acid (15 mL) was added to a solution of hydrazine hydrate (0.62 mL, 10 mmol) in acetic acid (2 mL). The resulting mixture was stirred at reflux for 2 h. The precipitate was collected and dried to give the title compound as a white solid (1.82 g, 95%).

Provenance & Evidence