Ammonium Chloride → HCID 66672833, compound

Participants

Reaction Steps

Fe powder (1.30 g, 23.2 mmol) and NH4Cl (69 mg, 1.3 mmol) were added to a suspension of 2-bromo-5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one (896 mg, 2.58 mmol) in 4:1 EtOH/H2O (60 mL) and the resulting suspension was heated at reflux for 14 h. The suspension was filtered through Celite, while warm, and the filtrate was concentrated to afford 800 mg of crude 5-(4-amino-3-methylphenyl)-2-bromofuro[3,2-c]pyridin-4(5H)-one as a yellow solid.

Provenance & Evidence