Cesium carbonate → HCID 58015560, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-chlorophenyl)-5H-furo[3,2-c]pyridine-4-one (1.00 g, 4.08 mmol) in DMF (9.46 mL) was added 5-fluoro-2-nitrotoluene (0.57 mL, 4.7 mmol) and Cs2CO3 (1.32 g, 4.08 mmol). After stirring at 120° C. for 48 h, the reaction mixture was cooled and the solids were collected by filtration. The solids were washed with EtOAc (300 ml) to yield the title compound (1.22 g, 78%) as a golden yellow solid: 1H NMR (500 MHz, DMSO-d6) δ 8.14 (d, J=8.6 Hz, 1H), 7.97 (t, J=17 Hz, 1H), 7.86 (d, J=6.9 Hz, 1H), 7.74 (s, 1H), 7.73 (d, J=7.0 Hz, 1H), 7.68 (d, J=2 Hz, 1H), 7.60 (dd, J=8.0, 2.2 Hz, 1H), 7.53 (t, J=8.0 Hz, 1H), 7.46-7.44 (m, 1H), 6.97 (d, J=7.5 Hz, 1H), 2.58 (s, 3H).

Provenance & Evidence