Ammonium Chloride → HCID 58015562, compound

Participants

Reaction Steps

A solution of 2-(3-chlorophenyl)-5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one (1.20 g, 3.15 mmol) in EtOH (21.2 mL) and H2O (5.16 mL) was treated with iron powder (152 g, 28.3 mmol) and NH4Cl (72.2 mg, 1.35 mmol). After stirring at reflux for 18 h, the reaction mixture was filtered through Celite® and the filtrate was concentrated to yield the title compound (1.02 g, 92%) as a light orange solid: 1H NMR (300 MHz, DMSO-d6) δ 7.95 (s, 1H), 7.84 (d, J=7.5 Hz, 1H), 7.67 (s, 1H), 7.55-7.42 (m, 3H), 6.94-6.78 (m, 3H), 6.67 (d, J=8.4 Hz, 1H), 5.11 (s, 2H), 2.09 (s, 3H).

Provenance & Evidence