Iodoethane → 2-Chloro-5-ethoxy-4-iodopyridine

Participants

Role	Name	HCID	Charge
Reactant	Iodoethane	HCID 6340	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	6-Chloro-4-iodopyridin-3-ol	HCID 53302038	—
Solvent	Dimethylformamide	HCID 6228	—
Product	2-Chloro-5-ethoxy-4-iodopyridine	HCID 53438320	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

Treat a solution of 6-chloro-4-iodo-pyridin-3-ol (4.9 g, 19 mmol) and potassium carbonate (8.0 g, 58 mmol) in dimethylformamide (50 mL) with ethyl iodide (4.7 mL, 58 mmol). Heat at 60° C. for 3 hours. Cool the mixture to room temperature and filter.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08101628B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-ab5fcc9c5611415eb0792743aeb0835d
Source note	uspto-grants-2012_01