Dimethylformamide → HCID 11849611, compound

Participants

Reaction Steps

2-Chloro-5-bromopyrimidine and p-cyanophenylboronic acid were reacted under the above-mentioned Suzuki coupling conditions to give the target dinitrile. Yield 91%, mp 305-306.5° C. (DMF). 1H NMR (DMSO-d6): δ 7.98-8.07 (m, 6H), 8.58 (s, 2H), 9.34 (s, 2H). 13C NMR (DMSO-d6): δ 161.1, 155.5, 140.4, 137.8, 132.6, 132.3, 129.9, 128.0, 127.4, 118.06, 118.00, 113.0, 111.3. MS (ESI) m/e (rel. int.): 282 (M+, 100), 141 (10), 127 (80).

Provenance & Evidence