反应详情

A mixture of S-3-methoxy-5-methylphenyl dimethylcarbamothioate (10) (4.10 g, 18.2 mmol) and KOH (6.0 g) in MeOH (200 mL) was refluxed for 2 h. After cooling, the mixture was concentrated and diluted with EtOAc (500 mL). The organics were washed with 1N HCl (50 mL), brine (2×50 mL), dried (Na2SO4), and concentrated to give 3-methoxy-5-methylbenzenethiol (11) (2.80 g, quant.) as a colourless oil.

1. temperaturewas refluxed for 2 h
2. temperatureAfter cooling
3. concentrationthe mixture was concentrated
4. additiondiluted with EtOAc (500 mL)
5. washThe organics were washed with 1N HCl (50 mL), brine (2×50 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated