HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → 2-(4-(Pyridin-2-yl)but-3-ynyl)benzo[d]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | 2-(But-3-yn-1-yl)-1,3-benzothiazole | HCID 57053628 | — |
| Product | 2-(4-(Pyridin-2-yl)but-3-ynyl)benzo[d]thiazole | HCID 11499940 | 45% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (127 mg, 0.80 mmol) and 2-(but-3-ynyl)benzo[d]thiazole (150 mg, 0.80 mmol). Reaction time: 1 day. The crude residue was purified by flash chromatography (DCM/MeOH 99:1) to yield 96 mg (0.36 mmol, 45%) of 2-(4-(pyridin-2-yl)but-3-ynyl)benzo[d]thiazole as an orange solid (M.P.=98.5-99.4° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101637B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-e6951d28ebfa4a339d5cdca7a5e730dc |
| Source note | uspto-grants-2012_01 |