HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-6-methylpyridine → 2-(4-(6-Methylpyridin-2-yl)but-3-ynyl)benzo[d]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-6-methylpyridine | HCID 79205 | — |
| Reactant | 2-(But-3-yn-1-yl)-1,3-benzothiazole | HCID 57053628 | — |
| Product | 2-(4-(6-Methylpyridin-2-yl)but-3-ynyl)benzo[d]thiazole | HCID 66598206 | 68.8% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 1, from 2-bromo-6-methyl-pyridine (110 mg, 0.64 mmol) and 2-but-3-ynyl-benzo[d]thiazole (120 mg, 0.64 mmol, Example 35(A)). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 7:3) to yield 122 mg (0.44 mmol, 68%) of 2-(4-(6-methylpyridin-2-yl)but-3-ynyl)benzo[d]thiazole as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101637B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-b5b1a5c6dcd54ca5ba326c9fe5ddf660 |
| Source note | uspto-grants-2012_01 |